Alterations in Some Biochemical Parameters and Trace Elements in Asthmatic Patients in Owerri

Abstract

Background:Asthma is a chronic disease characterized by recurrent cough and wheeze. Aim and Objectives: To determine the level of some biochemical parameters and trace elements in asthmatic patients attending General Hospital Owerri. Material and Methods: Thirty six confirmed asthmatic patients and thirty six apparently healthy subjects (control) between the age of 10 to 30 years were selected in this study. Serum trace elements: Zinc and copper, malondialdehyde, vitamin C, vitamin E, immunoglobulin A and immunoglobulin E were estimated using standard methods. Results: There serum levels of copper, IgE, IgA and MDA were significantly increased in asthmatic patients when compared to control (p<0.05). While the serum levels of zinc, vitamin C and vitamin E were significantly decreased in asthmatic patients when compared with the control (P< 0.05). Conclusion: These observations probably indicated that asthmatic patients could be prone to the oxidative stress. Also, foods or diets containing antioxidants could be beneficial to asthmatic patients.

Keywords

• Trace Elements
• Asthma
• Antioxidants
• Imunoglobulins