Seroprevalence of Antibodies Against Salmonella Enterica in a Healthy Population

Abstract

Background: In poor nations like India, enteric fever is a severe health issue. For the purpose of diagnosing enteric fever, the Widal test is frequently utilized. In the Western Region of India, this study attempted to measure the baseline antibody titres for Salmonella typhi and paratyphi A, B in healthy persons. Methods: A total of 150 blood samples from healthy persons were taken, and the pattern of antibody titre was determined using the conventional quantitative tube method. Results: Among 150 blood samples, 103 had shown significant antibody titres (≥ 1:20). The significant proportion (10.7%) of the individuals had anti-O titre ≥ 1:80. Similarly, 86 had anti-H titres of ≥ 1:20 to S. enteric serotype typhi, 23 had a titre of ≥1:80 and 4 had a titre of ≥1:160 respectively. We found 10% and 1.3% for paratyphi A and B, anti-H titres of ≥ 1:20respectively. Conclusion: The study's findings suggest that the Western Development Region of India should modify the threshold values for antibody titres against S. typhi to > 1:80 for both anti-O and anti-H titres.

Keywords

• Seroprevalence
• Widal test
• S. typhi
• S. paratyphi
• Salmonella
• Enteric fever