Comparison of Ketorolac and Ibuprofen IV Infusion Effect on Radius Distal Fracture Pain Control

Abstract

Background and Objective: Pain is one of the most common complaints in emergency departments of trauma centers. Opioid and Non-steroidal (NSAIDs) drugs are the most widely used medications for pain control in the emergency unit. This study was aimed to compare the analgesic effects of Ibuprofen and ketorolac in patients with radius fracture. Materials and Methods: This study was a randomized clinical trial evaluating 150 patients with distal radius fractures referring to emergency department of Besat hospital in Hamadan between 2016 and 2017. Patients were randomly placed in two intervention groups. The first group received IV ibuprofen 400 mg and the other group received IV ketorolac 30 mg which were infused for 30 min in both groups. The severity of pain was recorded ten min before the injection and every 30 min until 1 h after injection. Patients pain score and side effects were recorded in the data sheath and data were analyzed using statistical tests and SPSS (version 16). Results: A total of 97 males and 53 females with the mean age of 35.72 years were included in the study .There was no significant difference in the average pain scores measured by Numeric rating scale (NRS) before prescribing medications. The reduction in pain was more significant in the ketorolac group 30 min after injection (P<0.05). Conclusion: IV ketorolac 30 mg infusion is a safer and more effective method than IV ibuprofen 400 mg infusion for pain control in distal radius fracture following trauma.

Keywords

• ibuprofen
• ketorolac
• pain
• radius distal fractures