The 3’ End Prothrombin Gene Variants in Serbian Patients with Idiopathic Thrombophilia

Abstract

Thrombophilia is a multifactorial disorder that arises from the interaction of acquired and genetic risk factors. Despite the significant efforts made to understand the etiology of this disease, there are still a certain number of patients suffering from idiopathic thrombophilia. The aim of this study was to screen the 3’ end of the prothrombin (FII) gene, which is susceptible to gain-of-function mutations due to its non canonical architecture, in patients with idiopathic thrombophilia and to determine its eventual role in the pathogenesis of thrombophilia.

Keywords

• 3’ end prothrombin (fii) gene
• gene variants
• thrombophilia