Nature Communications (Mar 2017)

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

  • Martin S. Davey,
  • Carrie R. Willcox,
  • Stephen P. Joyce,
  • Kristin Ladell,
  • Sofya A. Kasatskaya,
  • James E. McLaren,
  • Stuart Hunter,
  • Mahboob Salim,
  • Fiyaz Mohammed,
  • David A. Price,
  • Dmitriy M. Chudakov,
  • Benjamin E. Willcox

DOI
https://doi.org/10.1038/ncomms14760
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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γδ T cells are generally considered innate‐like lymphocytes. Here the authors sequence human γδ T cell receptors (TCR) to show focusing of the private Vδ1 TCR repertoire, suggesting that, unlike Vδ2 T cells, the Vδ1 T cell compartment has adaptive attributes.