Progress and perspective of organoid technology in cancer-related translational medicine

Yusheng Lin; Li Jiang; Qiaojun He; Meng Yuan; Ji Cao

Biomedicine & Pharmacotherapy (May 2022)

Progress and perspective of organoid technology in cancer-related translational medicine

Yusheng Lin,
Li Jiang,
Qiaojun He,
Meng Yuan,
Ji Cao

Affiliations

Yusheng Lin: Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
Li Jiang: Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
Qiaojun He: Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China; The Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, China; Cancer Center of Zhejiang University, Hangzhou, China
Meng Yuan: The Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, China; Correspondence to: The Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Room 407, Hangzhou 310018, China.
Ji Cao: Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China; The Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, China; Cancer Center of Zhejiang University, Hangzhou, China; Correspondence to: College of Pharmaceutical Sciences, Zhejiang University, Room 115, No.866 Yuhangtang Rd, Hangzhou 310058, China.

Journal volume & issue: Vol. 149
p. 112869

Abstract

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Organoids are in vitro simplified and miniature microcosms of internal organs, which have aroused great interest in tissue development, multiple disease models, clinical diagnosis, as well as high-throughput drug screening and personalized medicine and so on. The success of physiology-related organoid culture has greatly advanced the translational medicine research in the field of cancer treatment, which was once troubled by the inconsistency between two-dimensional (2D) cell culture and in vivo studies. Especially in recent years, the success rate of establish an organoid has been greatly improved, and the types of organoids have been gradually enriched. Moreover, the utilizing of some the cutting-edge technologies, including gene editing technology such as CRISPR-Cas9, the scope of application of organoid is broadened. In this review, we discuss the latest progress and applications of organoids, and also outline the potential challenges of organoids for future improvement.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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