Nature Communications (Jan 2021)
Granzyme B inhibition reduces disease severity in autoimmune blistering diseases
- Sho Hiroyasu,
- Matthew R. Zeglinski,
- Hongyan Zhao,
- Megan A. Pawluk,
- Christopher T. Turner,
- Anika Kasprick,
- Chiharu Tateishi,
- Wataru Nishie,
- Angela Burleigh,
- Peter A. Lennox,
- Nancy Van Laeken,
- Nick J. Carr,
- Frank Petersen,
- Richard I. Crawford,
- Hiroshi Shimizu,
- Daisuke Tsuruta,
- Ralf J. Ludwig,
- David J. Granville
Affiliations
- Sho Hiroyasu
- International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute (VCHRI)
- Matthew R. Zeglinski
- International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute (VCHRI)
- Hongyan Zhao
- International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute (VCHRI)
- Megan A. Pawluk
- International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute (VCHRI)
- Christopher T. Turner
- International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute (VCHRI)
- Anika Kasprick
- Lübeck Institute of Experimental Dermatology, University of Lübeck
- Chiharu Tateishi
- Department of Dermatology, Osaka City University Graduate School of Medicine
- Wataru Nishie
- Department of Dermatology, Hokkaido University Graduate School of Medicine
- Angela Burleigh
- Department of Dermatology and Skin Science, UBC
- Peter A. Lennox
- Department of Surgery, UBC
- Nancy Van Laeken
- Department of Surgery, UBC
- Nick J. Carr
- Department of Surgery, UBC
- Frank Petersen
- Priority Area Asthma and Allergy, Members of the German Center for Lung Research, Research Center Borstel
- Richard I. Crawford
- Department of Pathology and Laboratory Medicine, University of British Columbia (UBC)
- Hiroshi Shimizu
- Department of Dermatology, Hokkaido University Graduate School of Medicine
- Daisuke Tsuruta
- Department of Dermatology, Osaka City University Graduate School of Medicine
- Ralf J. Ludwig
- Lübeck Institute of Experimental Dermatology, University of Lübeck
- David J. Granville
- International Collaboration On Repair Discoveries (ICORD) Centre, Vancouver Coastal Health Research Institute (VCHRI)
- DOI
- https://doi.org/10.1038/s41467-020-20604-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Pemphigoid diseases involve autoimmune mediated blistering and immunopathology of the upper dermis. Here, the authors implicate granzyme B in the immunopathology in multiple in vivo models of pemphigoid diseases and utilise a topical granzyme B inhibitor that attenuates disease phenotypes in vivo.
