Nature Communications (Dec 2020)
Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
- Oshrat Levi-Galibov,
- Hagar Lavon,
- Rina Wassermann-Dozorets,
- Meirav Pevsner-Fischer,
- Shimrit Mayer,
- Esther Wershof,
- Yaniv Stein,
- Lauren E. Brown,
- Wenhan Zhang,
- Gil Friedman,
- Reinat Nevo,
- Ofra Golani,
- Lior H. Katz,
- Rona Yaeger,
- Ido Laish,
- John A. Porco,
- Erik Sahai,
- Dror S. Shouval,
- David Kelsen,
- Ruth Scherz-Shouval
Affiliations
- Oshrat Levi-Galibov
- Department of Biomolecular Sciences, The Weizmann Institute of Science
- Hagar Lavon
- Department of Biomolecular Sciences, The Weizmann Institute of Science
- Rina Wassermann-Dozorets
- Department of Biomolecular Sciences, The Weizmann Institute of Science
- Meirav Pevsner-Fischer
- Department of Biomolecular Sciences, The Weizmann Institute of Science
- Shimrit Mayer
- Department of Biomolecular Sciences, The Weizmann Institute of Science
- Esther Wershof
- The Francis Crick Institute
- Yaniv Stein
- Department of Biomolecular Sciences, The Weizmann Institute of Science
- Lauren E. Brown
- Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University
- Wenhan Zhang
- Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University
- Gil Friedman
- Department of Biomolecular Sciences, The Weizmann Institute of Science
- Reinat Nevo
- Department of Biomolecular Sciences, The Weizmann Institute of Science
- Ofra Golani
- Department of Life Sciences Core Facilities, The Weizmann Institute of Science
- Lior H. Katz
- Gastroenterology Institute, Sheba Medical Center, Tel Hashomer
- Rona Yaeger
- Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, and Weil Cornell Medical College
- Ido Laish
- Gastroenterology Institute, Sheba Medical Center, Tel Hashomer
- John A. Porco
- Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University
- Erik Sahai
- The Francis Crick Institute
- Dror S. Shouval
- Sackler Faculty of Medicine, Tel-Aviv University
- David Kelsen
- Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, and Weil Cornell Medical College
- Ruth Scherz-Shouval
- Department of Biomolecular Sciences, The Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-020-20054-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
Expression and activation of Heat shock factor 1 (HSF1) in cancer associated fibroblasts have been associated with protumorigenic functions. Here the authors show that, in a model of colitis-induced colorectal cancer, HSF1 is activated in stromal fibroblasts in the early stages of inflammation, leading to extracellular matrix remodelling that sustains tumor initiation and progression.
