Mutations of p53 gene in canine sweat gland carcinomas probably associated with UV radiation

Abstract

Apocrine sweat gland carcinomas (ASGCs) are rare malignant skin tumours in dogs and humans. The literature published so far focuses mostly on the clinico-epidemiological aspect of these tumours, but little is known about their pathogenesis. In this study we aimed to determine whether the p53 gene is involved in the carcinogenesis of the apocrine sweat gland in dogs and whether ultraviolet radiation (UV) is related to it.

Keywords

• dog
• apocrine sweat gland carcinoma
• p53 gene, mutations
• uvr