Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance

Abstract

Introduction To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7. Methods The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR. Results The area of spleen fibrosis in the model group was significantly larger than that in the control group (p < 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group (p < 0.01). Conclusions CXCL12-CXCR4/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism.

Keywords

• liver cirrhosis with hypersplenism
• animal experiment
• spleen fibrosis
• chemotactic axis cxcl12-cxcr4/cxcr7
• therapeutic significance