Effect of adrenalectomy on the diurnal variation of hepatic cholesterogenesis in the rat

Peter E. Hickman; Brian J. Horton; John R. Sabine

Journal of Lipid Research (Jan 1972)

Effect of adrenalectomy on the diurnal variation of hepatic cholesterogenesis in the rat

Peter E. Hickman,
Brian J. Horton,
John R. Sabine

Affiliations

Peter E. Hickman: Department of Animal Physiology, Waite Agricultural Research Institute, University of Adelaide, Adelaide, S.A., Australia
Brian J. Horton: Department of Animal Physiology, Waite Agricultural Research Institute, University of Adelaide, Adelaide, S.A., Australia
John R. Sabine: Department of Animal Physiology, Waite Agricultural Research Institute, University of Adelaide, Adelaide, S.A., Australia

Journal volume & issue: Vol. 13, no. 1
pp. 17 – 22

Abstract

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The diurnal variation in cholesterol synthesis exhibited by rat liver has been examined in fed, fasted, and adrenalectomized animals.Fasting for 3 days caused a lowering of the rate of synthesis but did not abolish the diurnal rhythm. Adrenalectomy abolished the diurnal variation, and caused synthesis to remain at a uniformly high level. We suggest that corticosterone may play an essential role in the daily rhythm of cholesterogenesis.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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