Therapeutic potential of mesenchymal stem cell-derived exosomes and miRNAs in neuronal regeneration and rejuvenation in neurological disorders: a mini review

Aria Salehpour; Zahra Karimi; Mokhtar Ghasemi Zadeh; Mokhtar Ghasemi Zadeh; Mohammadreza Afshar; Mohammadreza Afshar; Ali Kameli; Fatemeh Mooseli; Fatemeh Mooseli; Masoud Zare; Alireza Afshar; Alireza Afshar

doi:10.3389/fncel.2024.1427525

Frontiers in Cellular Neuroscience (Oct 2024)

Therapeutic potential of mesenchymal stem cell-derived exosomes and miRNAs in neuronal regeneration and rejuvenation in neurological disorders: a mini review

Aria Salehpour,
Zahra Karimi,
Mokhtar Ghasemi Zadeh,
Mokhtar Ghasemi Zadeh,
Mohammadreza Afshar,
Mohammadreza Afshar,
Ali Kameli,
Fatemeh Mooseli,
Fatemeh Mooseli,
Masoud Zare,
Alireza Afshar,
Alireza Afshar

Affiliations

Aria Salehpour: The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Zahra Karimi: The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Mokhtar Ghasemi Zadeh: The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Mokhtar Ghasemi Zadeh: Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
Mohammadreza Afshar: The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Mohammadreza Afshar: Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
Ali Kameli: The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Fatemeh Mooseli: The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Fatemeh Mooseli: Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
Masoud Zare: The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Alireza Afshar: The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Alireza Afshar: Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran

DOI: https://doi.org/10.3389/fncel.2024.1427525
Journal volume & issue: Vol. 18

Abstract

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Mesenchymal stem cells (MSCs) have gained considerable attention in the field of regenerative medicine due to their ability to secrete small extracellular vesicles (EVs) known as exosomes. This review delves into the various biological activities of MSCs and the cell interactions enabled by these exosomes, with a focus on their potential for neuronal regeneration and the treatment of neurological disorders. We scrutinize findings from multiple studies that underscore the neuroprotective and neuro-regenerative effects of exosomes derived from MSCs, illuminating their mechanisms of action and therapeutic applications. This review thoroughly investigates all related pathways, miRNAs, and factors to suggest potential strategies for enhancing therapy for neurological disorders using exosomes and miRNAs, and for boosting neuronal regeneration.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

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Abstract

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