mBio (Jun 2021)
Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain
- Cyrille Mathieu,
- Francesca T. Bovier,
- Marion Ferren,
- Nicole A. P. Lieberman,
- Camilla Predella,
- Alexandre Lalande,
- Vikas Peddu,
- Michelle J. Lin,
- Amin Addetia,
- Achchhe Patel,
- Victor Outlaw,
- Barbara Corneo,
- N. Valerio Dorrello,
- Thomas Briese,
- Diana Hardie,
- Branka Horvat,
- Anne Moscona,
- Alexander L. Greninger,
- Matteo Porotto
Affiliations
- Cyrille Mathieu
- ORCiD
- Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA
- Francesca T. Bovier
- Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA
- Marion Ferren
- Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA
- Nicole A. P. Lieberman
- Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA
- Camilla Predella
- Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA
- Alexandre Lalande
- CIRI, Centre International de Recherche en Infectiologie, Team Immuno-Biology of Viral Infections, University of Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France
- Vikas Peddu
- Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA
- Michelle J. Lin
- Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA
- Amin Addetia
- Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA
- Achchhe Patel
- Stem Cell Core Facility, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA
- Victor Outlaw
- ORCiD
- Department of Chemistry, University of Wisconsin–Madison, Madison, Wisconsin, USA
- Barbara Corneo
- Stem Cell Core Facility, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA
- N. Valerio Dorrello
- Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA
- Thomas Briese
- Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA
- Diana Hardie
- Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town and National Health Laboratory Service, Cape Town, South Africa
- Branka Horvat
- ORCiD
- CIRI, Centre International de Recherche en Infectiologie, Team Immuno-Biology of Viral Infections, University of Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France
- Anne Moscona
- Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA
- Alexander L. Greninger
- Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA
- Matteo Porotto
- ORCiD
- Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA
- DOI
- https://doi.org/10.1128/mBio.00799-21
- Journal volume & issue
-
Vol. 12,
no. 3
Abstract
Measles virus (MeV) infection can cause serious complications in immunocompromised individuals, including measles inclusion body encephalitis (MIBE). In some cases, MeV persistence and subacute sclerosing panencephalitis (SSPE), another severe central nervous system (CNS) complication, develop even in the face of a systemic immune response.
