RISK FACTORS OF CYTOMEGALOVIRUS INFECTION DURING PREGNANCY

Abstract

The aim of this study was to assess the risk of infection by the detection of Cytomegalovirus (CMV) DNA in abortive samples in women with pregnancy loss. Material/Methods: Cross sectional study was designed to examine women with miscarriage. For six months, an abortive sample of 40 women hospitalized in Clinic of obstetrics and gynecology, University hospital-Pleven, Bulgaria were examined. By DNA-sorb-AM-AmpliSens DNA extraction was performed. The detection of cytomegalovirus DNA was performed by AmpliSens CMV – Eph PCR kit. The demographic data of the patients were collected by a questionnaire. The study protocol was approved by ethics committee of the Medical University - Pleven. Results: CMV DNA was detected in 16/40 (40%) of the women. In women up to 20 years of age (n=12), two positive samples were found. In women aged between 21 and 30 years of age, (n=12), six positive samples were found. The highest number of positive samples – 8 was found in women over 30 years of age (n=16). In the surveyed group, 18 (45%) were from minority groups, 32 (80%) were pregnant, low social status was found in about 80% of women. Conclusions: Our results indicate that there is a high frequency of CMV DNA in abortive samples from women who lost their pregnancy. Routine serologic screening for CMV of pregnant women will be advance in the understanding of CMV infection among pregnant women and its prevention.

Keywords

• CMV DNA
• frequency
• pregnancy loss
• risk factors