Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms

Sébastien Valverde; Marie Vandecasteele; Charlotte Piette; Willy Derousseaux; Giuseppe Gangarossa; Asier Aristieta Arbelaiz; Jonathan Touboul; Bertrand Degos; Laurent Venance

doi:10.1038/s41467-020-16046-6

Nature Communications (May 2020)

Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms

Sébastien Valverde,
Marie Vandecasteele,
Charlotte Piette,
Willy Derousseaux,
Giuseppe Gangarossa,
Asier Aristieta Arbelaiz,
Jonathan Touboul,
Bertrand Degos,
Laurent Venance

Affiliations

Sébastien Valverde: Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, MemoLife Labex
Marie Vandecasteele: Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, MemoLife Labex
Charlotte Piette: Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, MemoLife Labex
Willy Derousseaux: Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, MemoLife Labex
Giuseppe Gangarossa: Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, MemoLife Labex
Asier Aristieta Arbelaiz: Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, MemoLife Labex
Jonathan Touboul: Department of Mathematics and Volen National Center for Complex Systems, Brandeis University
Bertrand Degos: Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, MemoLife Labex
Laurent Venance: Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR7241/INSERM U1050, MemoLife Labex

DOI: https://doi.org/10.1038/s41467-020-16046-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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Deep brain stimulation (DBS) is a symptomatic treatment of Parkinson’s disease (PD) that benefits only a minority of patients. Here, the authors show that activation of cortical somatostatin interneurons alleviates motor symptoms in a mouse model of PD and may constitute a less invasive alternative than DBS.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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