Eculizumab for paroxysmal nocturnal hemoglobinuria: Two cases of successful pregnancy outcomes

Abstract

Key Clinical Message Paroxysmal nocturnal hemoglobinuria is a rare disease with the incidence ranging from 0.08 to 0.57 per 100,000 person‐years. Up to 25% of cases in women are detected during pregnancy. We report two cases of successful pregnancy outcomes in patients treated with eculizumab, pointing out the importance of interdisciplinary approach in these high‐risk pregnancies.

Keywords

• eculizumab
• paroxysmal nocturnal hemoglobinuria
• PNH
• pregnancy