Measure Twice: Promise of Liquid Biopsy in Pediatric High-Grade Gliomas

Matthew S. Dietz, DO; Catherine Z. Beach, BA; Ramon Barajas, MD; Michael S. Parappilly, BS; Sidharth K. Sengupta, BS; Lissa C. Baird, MD; Jeremy N. Ciporen, M; Seunggu J. Han, MD; Rebecca Loret de Mola, DO; Yoon Jae Cho, MD; Kellie J. Nazemi, MD; Shearwood McClelland, III, MD; Melissa H. Wong, PhD; Jerry J. Jaboin, MD, PhD

Advances in Radiation Oncology (Mar 2020)

Measure Twice: Promise of Liquid Biopsy in Pediatric High-Grade Gliomas

Matthew S. Dietz, DO,
Catherine Z. Beach, BA,
Ramon Barajas, MD,
Michael S. Parappilly, BS,
Sidharth K. Sengupta, BS,
Lissa C. Baird, MD,
Jeremy N. Ciporen, M,
Seunggu J. Han, MD,
Rebecca Loret de Mola, DO,
Yoon Jae Cho, MD,
Kellie J. Nazemi, MD,
Shearwood McClelland, III, MD,
Melissa H. Wong, PhD,
Jerry J. Jaboin, MD, PhD

Affiliations

Matthew S. Dietz, DO: Department of Pediatrics, Oregon Health & Science University, Portland, Oregon
Catherine Z. Beach, BA: Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon
Ramon Barajas, MD: Department of Diagnostic Radiology, Oregon Health & Science University, Portland, Oregon; Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon
Michael S. Parappilly, BS: Department of Diagnostic Radiology, Oregon Health & Science University, Portland, Oregon
Sidharth K. Sengupta, BS: Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon
Lissa C. Baird, MD: Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon
Jeremy N. Ciporen, M: Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon
Seunggu J. Han, MD: Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon
Rebecca Loret de Mola, DO: Department of Pediatrics, Oregon Health & Science University, Portland, Oregon
Yoon Jae Cho, MD: Department of Neurology, Oregon Health & Science University, Portland, Oregon; The Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon
Kellie J. Nazemi, MD: Department of Pediatrics, Oregon Health & Science University, Portland, Oregon
Shearwood McClelland, III, MD: Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana
Melissa H. Wong, PhD: Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon; The Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon
Jerry J. Jaboin, MD, PhD: Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon; The Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon; Corresponding author: Jerry J. Jaboin, MD, PhD

Journal volume & issue: Vol. 5, no. 2
pp. 152 – 162

Abstract

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Purpose: To review and critique the current state of liquid biopsy in pHGG. Materials and Methods: Published literature was reviewed for articles related to liquid biopsy in pediatric glioma and adult glioma with a focus on high-grade gliomas. Results: This review discusses the current state of liquid biomarkers of pHGG and their potential applications for liquid biopsy development. Conclusions: While nascent, the progress toward identifying circulating analytes of pHGG primes the field of neuro-oncoogy for liquid biopsy development.

Published in Advances in Radiation Oncology

ISSN: 2452-1094 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/advances-in-radiation-oncology/

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