Neuromodulation effects of deep brain stimulation on beta rhythm: A longitudinal local field potential study

Yue Chen; Chen Gong; Ye Tian; Natasza Orlov; Jianguo Zhang; Yi Guo; Shujun Xu; Changqing Jiang; Hongwei Hao; Wolf-Julian Neumann; Andrea A. Kühn; Hesheng Liu; Luming Li

Brain Stimulation (Nov 2020)

Neuromodulation effects of deep brain stimulation on beta rhythm: A longitudinal local field potential study

Yue Chen,
Chen Gong,
Ye Tian,
Natasza Orlov,
Jianguo Zhang,
Yi Guo,
Shujun Xu,
Changqing Jiang,
Hongwei Hao,
Wolf-Julian Neumann,
Andrea A. Kühn,
Hesheng Liu,
Luming Li

Affiliations

Yue Chen: National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, 10084, China
Chen Gong: National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, 10084, China
Ye Tian: National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, 10084, China
Natasza Orlov: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA
Jianguo Zhang: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China
Yi Guo: Department of Neurosurgery, Peking Union Medical College Hospital, Beijing, 100032, China
Shujun Xu: Department of Neurosurgery, Qilu Hospital of Shandong University, Shandong, 250012, China
Changqing Jiang: National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, 10084, China
Hongwei Hao: National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, 10084, China
Wolf-Julian Neumann: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, 10117, Germany
Andrea A. Kühn: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, 10117, Germany
Hesheng Liu: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA; Department of Neuroscience, Medical University of South Carolina, Charleston, 29425, SC, USA; Corresponding author. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Luming Li: National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing, 10084, China; Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, 518071, China; IDG/McGovern Institute for Brain Research at Tsinghua University, Beijing, 100084, China; Institute of Epilepsy, Beijing Institute for Brain Disorders, Beijing, 100093, China; Corresponding author. National Engineering Laboratory for Neuromodulation, Tsinghua University, Beijing, China.

Journal volume & issue: Vol. 13, no. 6
pp. 1784 – 1792

Abstract

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Background: Deep brain stimulation (DBS) holds great promise in treating various brain diseases but its chronic therapeutic mechanisms are unclear. Objective: To explore the immediate and chronic effects of DBS on brain oscillations, and understand how different sub-bands of oscillations may be related to symptom improvement in Parkinson's patients. Methods: We carried out a longitudinal study to examine the effects of DBS on local field potentials recorded by sensing-enabled neurostimulators in the subthalamic nuclei of Parkinson's patients, using a novel block-design stimulation paradigm. Results: DBS significantly suppressed beta activity (13–35Hz) but the suppression effect appeared to gradually attenuate during a 6-month follow-up period after surgery (p = 0.002). However, beta suppression did not attenuate after repeated stimulation over several minutes (p > 0.110), suggesting that the changes in beta suppression may reflect a slow reconfiguration of neural pathways instead of habituation. Suppression of beta was also associated with clinical symptom improvement across subjects. Importantly, symptom-relevant features fell within the high beta band at month 1 but shifted to the low beta band at month 6, indicating that the high beta and the low beta oscillations may play different functional roles and respond differently to stimulation over the long-term treatment. Conclusion: These data may advance understanding of chronic DBS effects on beta oscillations and their association with clinical improvement, offering novel insights to the therapeutic mechanisms of DBS.

Published in Brain Stimulation

ISSN: 1935-861X (Print); 1876-4754 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/brain-stimulation

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