GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models

Robert J. Torphy; Yi Sun; Ronggui Lin; Alayna Caffrey-Carr; Yuki Fujiwara; Felix Ho; Emily N. Miller; Martin D. McCarter; Traci R. Lyons; Richard D. Schulick; Ross M. Kedl; Yuwen Zhu

doi:10.1038/s41467-021-27658-x

Nature Communications (Jan 2022)

GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models

Robert J. Torphy,
Yi Sun,
Ronggui Lin,
Alayna Caffrey-Carr,
Yuki Fujiwara,
Felix Ho,
Emily N. Miller,
Martin D. McCarter,
Traci R. Lyons,
Richard D. Schulick,
Ross M. Kedl,
Yuwen Zhu

Affiliations

Robert J. Torphy: Department of Surgery, University of Colorado Anschutz Medical Campus
Yi Sun: Department of Surgery, University of Colorado Anschutz Medical Campus
Ronggui Lin: Department of Surgery, University of Colorado Anschutz Medical Campus
Alayna Caffrey-Carr: Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
Yuki Fujiwara: Department of Surgery, University of Colorado Anschutz Medical Campus
Felix Ho: Department of Surgery, University of Colorado Anschutz Medical Campus
Emily N. Miller: Department of Surgery, University of Colorado Anschutz Medical Campus
Martin D. McCarter: Department of Surgery, University of Colorado Anschutz Medical Campus
Traci R. Lyons: Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus
Richard D. Schulick: Department of Surgery, University of Colorado Anschutz Medical Campus
Ross M. Kedl: Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
Yuwen Zhu: Department of Surgery, University of Colorado Anschutz Medical Campus

DOI: https://doi.org/10.1038/s41467-021-27658-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Immunologically cold tumours don’t respond to immune checkpoint blockade inhibition due to poor recruitment of anti-tumour T cells. Authors show here that melanoma-associated lymphatic endothelial cells express G Protein-Coupled Receptor 182 that scavenges CXCL9 and other chemokines necessary for T cell recruitment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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