Cdk5 activation promotes Cos-7 cells transition towards neuronal-like cells

Bao Li; Lan Xiao-Mei; Zhang Guo-Qing; Bao Xi; Li Bo; Ma Dan-Na; Luo Hong-Yan; Cao Shi-Lu; Liu Shun-Yao; Jing E; Zhang Jian-Zhong; Zheng Ya-Li

doi:10.1515/tnsci-2022-0318

Translational Neuroscience (Oct 2023)

Cdk5 activation promotes Cos-7 cells transition towards neuronal-like cells

Bao Li,
Lan Xiao-Mei,
Zhang Guo-Qing,
Bao Xi,
Li Bo,
Ma Dan-Na,
Luo Hong-Yan,
Cao Shi-Lu,
Liu Shun-Yao,
Jing E,
Zhang Jian-Zhong,
Zheng Ya-Li

Affiliations

Bao Li: Department of Pathology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan750004, P.R. China
Lan Xiao-Mei: Graduate School of Xi’an Jiaotong University, Xi’an710061, P.R. China
Zhang Guo-Qing: Department of Pathology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan750004, P.R. China
Bao Xi: Department of Pathology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan750004, P.R. China
Li Bo: Department of Pathology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan750004, P.R. China
Ma Dan-Na: Department of Pathology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan750004, P.R. China
Luo Hong-Yan: Department of Pathology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan750004, P.R. China
Cao Shi-Lu: Department of Pathology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan750004, P.R. China
Liu Shun-Yao: Department of Pathology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan750004, P.R. China
Jing E: Department of Pathology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan750004, P.R. China
Zhang Jian-Zhong: Department of Pathology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan750004, P.R. China
Zheng Ya-Li: Department of Nephrology, Ningxia Medical University Affiliated People’s Hospital of Autonomous Region of Yinchuan, Yinchuan750002, P.R. China

DOI: https://doi.org/10.1515/tnsci-2022-0318
Journal volume & issue: Vol. 14, no. 1
pp. 8001 – 12

Abstract

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Cyclin-dependent kinase 5 (Cdk5) activity is specifically active in neurogenesis, and Cdk5 and neocortical neurons migration related biomarker are expressed in Cos-7 cells. However, the function of Cdk5 on the transformation of immortalized Cos-7 cells into neuronal-like cells is not clear.

Published in Translational Neuroscience

ISSN: 2081-6936 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.degruyter.com/view/j/tnsci

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Abstract

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