Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data

Fei Shen; Fei Shen; Xiaoxiong Gan; Xiaoxiong Gan; Ruiying Zhong; Jianhua Feng; Jianhua Feng; Zhen Chen; Zhen Chen; Mengli Guo; Mengli Guo; Yayi Li; Yayi Li; Zhaofeng Wu; Wensong Cai; Wensong Cai; Bo Xu; Bo Xu

doi:10.3389/fcell.2021.645275

Frontiers in Cell and Developmental Biology (Feb 2021)

Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data

Fei Shen,
Fei Shen,
Xiaoxiong Gan,
Xiaoxiong Gan,
Ruiying Zhong,
Jianhua Feng,
Jianhua Feng,
Zhen Chen,
Zhen Chen,
Mengli Guo,
Mengli Guo,
Yayi Li,
Yayi Li,
Zhaofeng Wu,
Wensong Cai,
Wensong Cai,
Bo Xu,
Bo Xu

Affiliations

Fei Shen: Department of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
Fei Shen: Department of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China
Xiaoxiong Gan: Department of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
Xiaoxiong Gan: Department of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China
Ruiying Zhong: Department of Hepatobiliary, Pancreatic and Splenic Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
Jianhua Feng: Department of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
Jianhua Feng: Department of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China
Zhen Chen: Department of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
Zhen Chen: Department of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China
Mengli Guo: Department of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
Mengli Guo: Department of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China
Yayi Li: Department of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
Yayi Li: Department of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China
Zhaofeng Wu: Department of Hepatobiliary, Pancreatic and Splenic Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
Wensong Cai: Department of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
Wensong Cai: Department of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China
Bo Xu: Department of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China
Bo Xu: Department of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, China

DOI: https://doi.org/10.3389/fcell.2021.645275
Journal volume & issue: Vol. 9

Abstract

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Thyroid carcinoma (TC) is the most common endocrine malignancy. The incidence rate of thyroid cancer has increased rapidly in recent years. The occurrence and development of thyroid cancers are highly related to the massive genetic and epigenetic changes. Therefore, it is essential to explore the mechanism of thyroid cancer pathogenesis. Genome-Wide Association Studies (GWAS) have been widely used in various diseases. Researchers have found multiple single nucleotide polymorphisms (SNPs) are significantly related to TC. However, the biological mechanism of these SNPs is still unknown. In this paper, we used one GWAS dataset and two eQTL datasets, and integrated GWAS with expression quantitative trait loci (eQTL) in both thyroid and blood to explore the mechanism of mutations and causal genes of thyroid cancer. Finally, we found rs1912998 regulates the expression of IGFALS (P = 1.70E-06) and HAGH (P = 5.08E-07) in thyroid, which is significantly related to thyroid cancer. In addition, KEGG shows that these genes participate in multiple thyroid cancer-related pathways.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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