Mechanical stress determines the configuration of TGFβ activation in articular cartilage

Gehua Zhen; Qiaoyue Guo; Yusheng Li; Chuanlong Wu; Shouan Zhu; Ruomei Wang; X. Edward Guo; Byoung Choul Kim; Jessie Huang; Yizhong Hu; Yang Dan; Mei Wan; Taekjip Ha; Steven An; Xu Cao

doi:10.1038/s41467-021-21948-0

Nature Communications (Mar 2021)

Mechanical stress determines the configuration of TGFβ activation in articular cartilage

Gehua Zhen,
Qiaoyue Guo,
Yusheng Li,
Chuanlong Wu,
Shouan Zhu,
Ruomei Wang,
X. Edward Guo,
Byoung Choul Kim,
Jessie Huang,
Yizhong Hu,
Yang Dan,
Mei Wan,
Taekjip Ha,
Steven An,
Xu Cao

Affiliations

Gehua Zhen: Department of Orthopaedic Surgery, The Johns Hopkins University
Qiaoyue Guo: Department of Orthopaedic Surgery, The Johns Hopkins University
Yusheng Li: Department of Orthopaedic Surgery, The Johns Hopkins University
Chuanlong Wu: Department of Orthopaedic Surgery, The Johns Hopkins University
Shouan Zhu: Department of Orthopaedic Surgery, The Johns Hopkins University
Ruomei Wang: Department of Orthopaedic Surgery, The Johns Hopkins University
X. Edward Guo: Department of Biomedical Engineering, Columbia University
Byoung Choul Kim: Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University
Jessie Huang: Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, The State University of New Jersey
Yizhong Hu: Department of Biomedical Engineering, Columbia University
Yang Dan: Department of Orthopaedic Surgery, The Johns Hopkins University
Mei Wan: Department of Orthopaedic Surgery, The Johns Hopkins University
Taekjip Ha: Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University
Steven An: Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, The State University of New Jersey
Xu Cao: Department of Orthopaedic Surgery, The Johns Hopkins University

DOI: https://doi.org/10.1038/s41467-021-21948-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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The functional relationship between subchondral bone and articular cartilage is unclear. Here, the authors show that transforming growth factor-beta propagates the mechanical impact of subchondral bone on articular cartilage through αV integrin–talin mechanical transduction system in chondrocytes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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