Nature Communications (Sep 2017)
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
- Aleksandra Deczkowska,
- Orit Matcovitch-Natan,
- Afroditi Tsitsou-Kampeli,
- Sefi Ben-Hamo,
- Raz Dvir-Szternfeld,
- Amit Spinrad,
- Oded Singer,
- Eyal David,
- Deborah R. Winter,
- Lucas K. Smith,
- Alexander Kertser,
- Kuti Baruch,
- Neta Rosenzweig,
- Anna Terem,
- Marco Prinz,
- Saul Villeda,
- Ami Citri,
- Ido Amit,
- Michal Schwartz
Affiliations
- Aleksandra Deczkowska
- Department of Neurobiology, Weizmann Institute of Science
- Orit Matcovitch-Natan
- Department of Neurobiology, Weizmann Institute of Science
- Afroditi Tsitsou-Kampeli
- Department of Neurobiology, Weizmann Institute of Science
- Sefi Ben-Hamo
- Department of Neurobiology, Weizmann Institute of Science
- Raz Dvir-Szternfeld
- Department of Neurobiology, Weizmann Institute of Science
- Amit Spinrad
- Department of Neurobiology, Weizmann Institute of Science
- Oded Singer
- Faculty of Biochemistry, Life Sciences Core Facilities, Weizmann Institute of Science
- Eyal David
- Department of Immunology, Weizmann Institute of Science
- Deborah R. Winter
- Department of Immunology, Weizmann Institute of Science
- Lucas K. Smith
- Department of Anatomy, University of California San Francisco
- Alexander Kertser
- Department of Neurobiology, Weizmann Institute of Science
- Kuti Baruch
- Department of Neurobiology, Weizmann Institute of Science
- Neta Rosenzweig
- Department of Neurobiology, Weizmann Institute of Science
- Anna Terem
- Department of Biological Chemistry, Institute of Life Sciences, Faculty of Natural Sciences, The Hebrew University
- Marco Prinz
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg
- Saul Villeda
- Department of Anatomy, University of California San Francisco
- Ami Citri
- Department of Biological Chemistry, Institute of Life Sciences, Faculty of Natural Sciences, The Hebrew University
- Ido Amit
- Department of Immunology, Weizmann Institute of Science
- Michal Schwartz
- Department of Neurobiology, Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-017-00769-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia ‘off’ signal.
