The Effect of Fermented Homemade-Style Yogurt in Helicobacter Pylori Eradication

Abstract

INTRODUCTION[|]Helicobacter pylori (Hp) infection is common worldwide and may be involved in the pathogenesis of gastritis, peptic ulcer, and gastric malignancy. Treatment has been effective; however, due to the increasing antibiotic resistance of Hp, there is renewed interest in research. Studies have indicated that the addition of probiotic yogurt to treatment may increase the rate of Hp eradication. This study was an investigation of the effect of the addition yogurt to the standard, first-line treatment on Hp eradication and patient compliance.[¤]METHODS[|]A total of 147 patients were included in the study. Patients who were diagnosed with Hp infection in an endoscopic examination using the histological method were given eradication treatment. The consumption of yogurt in the home was questioned. Patients who used at least 80% of the prescribed drugs were considered to have complied with the treatment. A stool antigen test was performed 4 weeks after the end of treatment to assess Hp eradication.[¤]RESULTS[|]Intention-to-treat analysis revealed that eradication was achieved in 50 (57.4%) of the 80 patients who received only first-line treatment and 21 (39%) of the 60 patients receiving yogurt + first-line treatment. Per-protocol analysis indicated that Hp eradication was achieved in 50 patients (76.9%) of the 65 patients who received yogurt + first-line treatment. Yogurt + first-line treatment had a better eradication rate (p=0.009; p=0.028).[¤]DISCUSSION AND CONCLUSION[|]The Hp eradication rate increased with the addition of yogurt added to the standard treatment. Factors such as age, gender, and education level did not affect eradication.[¤]

Keywords

• helicobacter
• eradication
• yogurt.