The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography

Hala Zuhayri; Viktor V. Nikolaev; Tatiana B. Lepekhina; Ekaterina A. Sandykova; Natalya A. Krivova; Yury V. Kistenev

doi:10.3390/pharmaceutics14020399

Pharmaceutics (Feb 2022)

The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography

Hala Zuhayri,
Viktor V. Nikolaev,
Tatiana B. Lepekhina,
Ekaterina A. Sandykova,
Natalya A. Krivova,
Yury V. Kistenev

Affiliations

Hala Zuhayri: Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Lenin Ave. 36, 634050 Tomsk, Russia
Viktor V. Nikolaev: Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Lenin Ave. 36, 634050 Tomsk, Russia
Tatiana B. Lepekhina: Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Lenin Ave. 36, 634050 Tomsk, Russia
Ekaterina A. Sandykova: Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Lenin Ave. 36, 634050 Tomsk, Russia
Natalya A. Krivova: Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Lenin Ave. 36, 634050 Tomsk, Russia
Yury V. Kistenev: Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Lenin Ave. 36, 634050 Tomsk, Russia

DOI: https://doi.org/10.3390/pharmaceutics14020399
Journal volume & issue: Vol. 14, no. 2
p. 399

Abstract

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The effect of low-dose photodynamic therapy on in vivo wound healing was investigated using optical coherence tomography. This work aims to develop an approach to quantitative assessment of the wound’s state during wound healing including the effect of low-dose photodynamic therapy using topical application of two different photosensitizers, 5-aminolevulinic acid and methylene blue, and two laser doses of 1 J/cm2 and 4 J/cm2. It was concluded that the laser dose of 4 J/cm2 was better compared to 1 J/cm2 and allowed the wound healing process to accelerate.

Published in Pharmaceutics

ISSN: 1999-4923 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceutics/

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