Journal of Laboratory Medicine (Oct 2023)

A new approach to the interpretation of B-type natriuretic peptide concentration in children with congenital heart disease

  • Svobodov Andrei A.,
  • Kupryashov Aleksei A.,
  • Dobroserdova Tatayna K.,
  • Levchenko Elena G.,
  • Tumanyan Margarita R.,
  • Anderson Aleksei G.

DOI
https://doi.org/10.1515/labmed-2022-0150
Journal volume & issue
Vol. 47, no. 5
pp. 225 – 232

Abstract

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BNP is the unique cardiac marker that reflects not as much as the degree of heart muscle damage, but mostly the severity of hemodynamic disorder, which is important in congenital heart disease. The only disadvantage of this marker is the barely studied reference values for children. It is known that the younger the child is, the higher the BNP value will be. By shifting from interpreting the absolute values towards the application of zlog-transformed data in clinical practice, we can overcome the above problems.

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