Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

Shiqian Qi; Zichong Li; Ursula Schulze-Gahmen; Goran Stjepanovic; Qiang Zhou; James H. Hurley

doi:10.1038/ncomms14076

Nature Communications (Jan 2017)

Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

Shiqian Qi,
Zichong Li,
Ursula Schulze-Gahmen,
Goran Stjepanovic,
Qiang Zhou,
James H. Hurley

Affiliations

Shiqian Qi: Department of Urology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and National Collaborative Innovation Center
Zichong Li: Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley
Ursula Schulze-Gahmen: Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley
Goran Stjepanovic: Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley
Qiang Zhou: Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley
James H. Hurley: Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley

DOI: https://doi.org/10.1038/ncomms14076
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

Read online

The host super elongation complex (SEC) is hijacked by HIV-1 for viral transcription. Here the authors present the structure of RNA polymerase elongation factor ELL2 bound to the intrinsically disordered scaffold protein AFF4, identifying an ELL2 surface important for HIV-1 transcription.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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