Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages

Rebecca Gupte; Tulip Nandu; W. Lee Kraus

doi:10.1038/s41467-021-24225-2

Nature Communications (Jun 2021)

Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages

Rebecca Gupte,
Tulip Nandu,
W. Lee Kraus

Affiliations

Rebecca Gupte: Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center
Tulip Nandu: Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center
W. Lee Kraus: Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-021-24225-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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STAT1a is required for pro-inflammatory responses in macrophages. Here the authors reveal that post-translational modification of STAT1a, ADPribosylation, plays a critical role in enhancer formation and activation, thus modulating IFNγ-stimulated inflammatory responses in macrophages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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