Communications Biology (May 2021)

Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin

  • Max-Aylmer Dreier,
  • Philipp Althoff,
  • Mohamad Javad Norahan,
  • Stefan Alexander Tennigkeit,
  • Samir F. El-Mashtoly,
  • Mathias Lübben,
  • Carsten Kötting,
  • Till Rudack,
  • Klaus Gerwert

DOI
https://doi.org/10.1038/s42003-021-02101-5
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 10

Abstract

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Dreier et al. reports that the anion channelrhodopsin GtACR1 does not undergo a syn-cycle (light adapted ground state) and thus has a more efficient channel behaviour than CrChR2. They propose that constructing variants lacking syn-cycle could optimize channelrhodopsin for optogenetic applications.