Frontiers in Neurology (Oct 2018)

Aberrant Sensory Gating of the Primary Somatosensory Cortex Contributes to the Motor Circuit Dysfunction in Paroxysmal Kinesigenic Dyskinesia

  • Yo-Tsen Liu,
  • Yo-Tsen Liu,
  • Yo-Tsen Liu,
  • Yo-Tsen Liu,
  • Yi-Chieh Chen,
  • Yi-Chieh Chen,
  • Shang-Yeong Kwan,
  • Shang-Yeong Kwan,
  • Chien-Chen Chou,
  • Chien-Chen Chou,
  • Hsiang-Yu Yu,
  • Hsiang-Yu Yu,
  • Der-Jen Yen,
  • Der-Jen Yen,
  • Kwong-Kum Liao,
  • Kwong-Kum Liao,
  • Wei-Ta Chen,
  • Wei-Ta Chen,
  • Wei-Ta Chen,
  • Wei-Ta Chen,
  • Yung-Yang Lin,
  • Yung-Yang Lin,
  • Yung-Yang Lin,
  • Yung-Yang Lin,
  • Yung-Yang Lin,
  • Rou-Shayn Chen,
  • Rou-Shayn Chen,
  • Kang-Yang Jih,
  • Kang-Yang Jih,
  • Shu-Fen Lu,
  • Yu-Te Wu,
  • Yu-Te Wu,
  • Yu-Te Wu,
  • Po-Shan Wang,
  • Po-Shan Wang,
  • Po-Shan Wang,
  • Po-Shan Wang,
  • Fu-Jung Hsiao,
  • Fu-Jung Hsiao

DOI
https://doi.org/10.3389/fneur.2018.00831
Journal volume & issue
Vol. 9

Abstract

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Paroxysmal kinesigenic dyskinesia (PKD) is conventionally regarded as a movement disorder (MD) and characterized by episodic hyperkinesia by sudden movements. However, patients of PKD often have sensory aura and respond excellently to antiepileptic agents. PRRT2 mutations, the most common genetic etiology of PKD, could cause epilepsy syndromes as well. Standing in the twilight zone between MDs and epilepsy, the pathogenesis of PKD is unclear. Gamma oscillations arise from the inhibitory interneurons which are crucial in the thalamocortical circuits. The role of synchronized gamma oscillations in sensory gating is an important mechanism of automatic cortical inhibition. The patterns of gamma oscillations have been used to characterize neurophysiological features of many neurological diseases, including epilepsy and MDs. This study was aimed to investigate the features of gamma synchronizations in PKD. In the paired-pulse electrical-stimulation task, we recorded the magnetoencephalographic data with distributed source modeling and time-frequency analysis in 19 patients of newly-diagnosed PKD without receiving pharmacotherapy and 18 healthy controls. In combination with the magnetic resonance imaging, the source of gamma oscillations was localized in the primary somatosensory cortex. Somatosensory evoked fields of PKD patients had a reduced peak frequency (p < 0.001 for the first and the second response) and a prolonged peak latency (the first response p = 0.02, the second response p = 0.002), indicating the synchronization of gamma oscillation is significantly attenuated. The power ratio between two responses was much higher in the PKD group (p = 0.013), indicating the incompetence of activity suppression. Aberrant gamma synchronizations revealed the defective sensory gating of the somatosensory area contributes the pathogenesis of PKD. Our findings documented disinhibited cortical function is a pathomechanism common to PKD and epilepsy, thus rationalized the clinical overlaps of these two diseases and the therapeutic effect of antiepileptic agents for PKD. There is a greater reduction of the peak gamma frequency in PRRT2-related PKD than the non-PRRT PKD group (p = 0.028 for the first response, p = 0.004 for the second response). Loss-of-function PRRT2 mutations could lead to synaptic dysfunction. The disinhibiton change on neurophysiology reflected the impacts of PRRT2 mutations on human neurophysiology.

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