Nature Communications (Mar 2016)
Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
- Ruben G. de Bruin,
- Lily Shiue,
- Jurriën Prins,
- Hetty C. de Boer,
- Anjana Singh,
- W. Samuel Fagg,
- Janine M. van Gils,
- Jacques M. G. J. Duijs,
- Sol Katzman,
- Adriaan O. Kraaijeveld,
- Stefan Böhringer,
- Wai Y. Leung,
- Szymon M. Kielbasa,
- John P. Donahue,
- Patrick H.J. van der Zande,
- Rick Sijbom,
- Carla M. A. van Alem,
- Ilze Bot,
- Cees van Kooten,
- J. Wouter Jukema,
- Hilde Van Esch,
- Ton J. Rabelink,
- Hilal Kazan,
- Erik A. L. Biessen,
- Manuel Ares Jr.,
- Anton Jan van Zonneveld,
- Eric P. van der Veer
Affiliations
- Ruben G. de Bruin
- Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center
- Lily Shiue
- Department of Molecular, Center for Molecular Biology of RNA, Cell and Developmental Biology, University of California
- Jurriën Prins
- Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center
- Hetty C. de Boer
- Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center
- Anjana Singh
- Department of Pathology, CARIM, Academic University Hospital Maastricht
- W. Samuel Fagg
- Department of Molecular, Center for Molecular Biology of RNA, Cell and Developmental Biology, University of California
- Janine M. van Gils
- Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center
- Jacques M. G. J. Duijs
- Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center
- Sol Katzman
- Department of Molecular, Center for Molecular Biology of RNA, Cell and Developmental Biology, University of California
- Adriaan O. Kraaijeveld
- Department of Cardiology, Leiden University Medical Center
- Stefan Böhringer
- Department of Medical Biostatistics, Leiden University Medical Center
- Wai Y. Leung
- Department of Sequencing Analysis Support Core, Leiden University Medical Center
- Szymon M. Kielbasa
- Department of Medical Biostatistics, Leiden University Medical Center
- John P. Donahue
- Department of Molecular, Center for Molecular Biology of RNA, Cell and Developmental Biology, University of California
- Patrick H.J. van der Zande
- Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center
- Rick Sijbom
- Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center
- Carla M. A. van Alem
- Department of Internal Medicine (Nephrology), Leiden University Medical Center
- Ilze Bot
- Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University
- Cees van Kooten
- Department of Internal Medicine (Nephrology), Leiden University Medical Center
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Hilde Van Esch
- Department of Human Genetics, University Hospitals Leuven
- Ton J. Rabelink
- Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center
- Hilal Kazan
- Department of Computer Engineering, Antalya International University
- Erik A. L. Biessen
- Department of Pathology, CARIM, Academic University Hospital Maastricht
- Manuel Ares Jr.
- Department of Molecular, Center for Molecular Biology of RNA, Cell and Developmental Biology, University of California
- Anton Jan van Zonneveld
- Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center
- Eric P. van der Veer
- Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center
- DOI
- https://doi.org/10.1038/ncomms10846
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 20
Abstract
Post-transcriptional control of RNA is important in health and disease. Here, the authors show that the RNA-binding protein Quaking guides pre-mRNA splicing and transcript abundance during monocyte to macrophage differentiation, and that Quaking depletion impairs pro-atherogenic foam cell formation.
