Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells

Chuna Kim; Sanghyun Sung; Jong-Seo Kim; Hyunji Lee; Yoonseok Jung; Sanghee Shin; Eunkyeong Kim; Jenny J. Seo; Jun Kim; Daeun Kim; Hiroyuki Niida; V. Narry Kim; Daechan Park; Junho Lee

doi:10.1038/s41467-021-21341-x

Nature Communications (Feb 2021)

Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells

Chuna Kim,
Sanghyun Sung,
Jong-Seo Kim,
Hyunji Lee,
Yoonseok Jung,
Sanghee Shin,
Eunkyeong Kim,
Jenny J. Seo,
Jun Kim,
Daeun Kim,
Hiroyuki Niida,
V. Narry Kim,
Daechan Park,
Junho Lee

Affiliations

Chuna Kim: Department of Biological Sciences, Seoul National University
Sanghyun Sung: Department of Biological Sciences, Seoul National University
Jong-Seo Kim: Department of Biological Sciences, Seoul National University
Hyunji Lee: Department of Biological Sciences, Seoul National University
Yoonseok Jung: Center for RNA Research, Institute for Basic Science
Sanghee Shin: Department of Biological Sciences, Seoul National University
Eunkyeong Kim: Department of Biological Sciences, Seoul National University
Jenny J. Seo: Department of Biological Sciences, Seoul National University
Jun Kim: Department of Biological Sciences, Seoul National University
Daeun Kim: Department of Biological Sciences, Ajou University
Hiroyuki Niida: Department of Molecular Biology, Hamamatsu University School of Medicine
V. Narry Kim: Department of Biological Sciences, Seoul National University
Daechan Park: Department of Biological Sciences, Ajou University
Junho Lee: Department of Biological Sciences, Seoul National University

DOI: https://doi.org/10.1038/s41467-021-21341-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Telomeres can be maintained by a telomerase-independent mechanism called an alternative lengthening of telomeres (ALT). Here the authors use mouse Terc (telomerase RNA) knockout embryonic cells and provide longitudinal analysis of ALT telomeres maintained with non-telomeric sequences.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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