New methods for laboratory diagnostics and control of efficiency of therapy of allergic diseases

Abstract

Laser correlation spectroscopy (LCS) and analysis of toxicity of patient serum and urine for bovine spermatozoa (AT), new methods for laboratory diagnostics and control of the efficiency of prescribed treatment, were first used in allergological clinical practice. These methods enable screening etiological diagnostics of allergic diseases and evaluation of the severity of the pathological process and state of defense systems of the organism during treatment. Adequate diagnostics makes it possible to realize individual choice of treatment protocol, due to which long-term remission can be expected. We examined 250 patients (mean age 34,4 ± 2 years) with documented allergic disease of medium severity and 145 healthy individuals (mean age 38,1 ± 1 years). Significant differences were revealed in the functional state of the defense systems in these groups. It was found that endogenous intoxication develops in the majority of patients; it is characterized by reduced index of blood toxicity (IBT) and elevated index of urine toxicity (IUT) as well as increased contribution of small particles of blood serum into light scatter. During therapy we observed a decrease in IUT, which attested to correction of the state of humoral defense system of the organism. Alleviation of the pathological state was confirmed by clinical findings. Our results suggest that new methods are highly informative and safe and should be introduced into allergologist's practics.