Medication Related Osteonecrosis of the Jaw (MRONJ). Review and recent advances

Abstract

Medication-Related Osteonecrosis of the Jaw (MRONJ) is defined as a complication, which affects the jawbone of patients that meet all of the following criteria: (a) patients were in the past or are now on treatment with bone targeting agents (BTAs) and/or antiangiogenics, (b) they have exposed bone or bone that can be probed through an intraoral or extraoral fistula for more than 8 weeks, and (c) they have no history of radiotherapy or obvious metastatic disease to the jaws.

Keywords

• osteonecrosis of the jaw
• clinical presentation
• radiographical findings
• risk factors
• prevention
• dental extraction
• infection
• management