Lupus Science and Medicine (Oct 2021)
Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network
- Andrew Filer,
- Michael H Weisman,
- Judith A James,
- Kenneth Kalunian,
- Michelle A Petri,
- Chaim Putterman,
- H Michael Belmont,
- Ilfita Sahbudin,
- Karim Raza,
- Maria Dall'Era,
- Jill P Buyon,
- Diane L Kamen,
- Karen Salomon-Escoto,
- Kazuyoshi Ishigaki,
- Patrick Dunn,
- David Wofsy,
- Michele Bombardieri,
- Vivian Bykerk,
- Myles Lewis,
- Ming Wu,
- Soumya Raychaudhuri,
- Hemant Suryawanshi,
- Thomas Tuschl,
- Christopher Ritchlin,
- Maureen McMahon,
- Jennifer Grossman,
- Philip M Carlucci,
- Alessandra Nerviani,
- Peter M Izmirly,
- Fan Zhang,
- Felice Rivellese,
- Joan Bathon,
- Zhu Zhu,
- Qian Xiao,
- Jessica Li,
- Holden Maecker,
- Nir Hacohen,
- Rong Mao,
- Jennifer Anolik,
- Javier Rangel-Moreno,
- Nida Meednu,
- Susan Goodman,
- Lindsy Forbess,
- Mariko Ishimori,
- Kevin Deane,
- David Hildeman,
- Yuhong Li,
- Laura Hughes,
- Robert Clancy,
- ANNE DAVIDSON,
- Matthias Kretzler,
- Larry Moreland,
- Harris Perlman,
- Peter Gregersen,
- Celine C Berthier,
- Andrea Fava,
- David Boyle,
- Derek M Fine,
- Ami Ben-Artzi,
- P J Utz,
- Melanie Smith,
- Beatrice Goilav,
- Carla Cuda,
- Andrew McDavid,
- Deepak A Rao,
- Joshua Keegan,
- Ilya Korsunsky,
- Joel Guthridge,
- Kevin Wei,
- Arnon Arazi,
- Thomas Eisenhaure,
- Michael Brenner,
- Susan Macwana,
- Pavel Morozov,
- Manjunath Kustagi,
- Gerald Watts,
- Kristina K Deonaraine,
- Jose Monroy-Trujillo,
- Mohamed G Atta,
- Kristin Haag,
- William Apruzzese,
- Sean Connery,
- Fernanda Payan-Schober,
- Kerry Cho,
- Jennifer Goff,
- Aparna Nathan,
- Joseph Mears,
- Nghia Millard,
- Kathryn Weinand,
- Saori Sakaue,
- Bill Robinson,
- Wade DeJager,
- Louis Bridges,
- Laura Donlin,
- Edward DiCarlo,
- Amit Lakhanpal,
- Heather Sherman,
- Anvita Singaraju,
- Lorien Shakib,
- Brendan Boyce,
- Darren Tabechian,
- Jen Albrecht,
- James Lederer,
- A Helena Jonsson,
- Daimon Simmons,
- Gregory Keras,
- Adam Chicoine,
- Zhihan Jian Li,
- Mandy McGeachy,
- Gary Firestein,
- Arnold Ceponis,
- Diane Horowitz,
- Salina Dominguez,
- Arthur Mandelin,
- Anjali Thakrar,
- Mike Holers,
- Jennifer Seifert,
- Constanino Pitzalis,
- Ellen Gravallese,
- Jennifer Barnas,
- Raymond Hsu,
- Steven Woodle,
- Paul Hoover,
- Michael Peters,
- Tony Jones,
- David Lieb,
- Jeffrey Hodgin,
- Raji Menon
Affiliations
- Andrew Filer
- Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
- Michael H Weisman
- School of Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California, USA
- Judith A James
- Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
- Kenneth Kalunian
- University of California San Diego School of Medicine, La Jolla, CA, USA
- Michelle A Petri
- Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA
- Chaim Putterman
- Division of Rheumatology and Department of Microbiology and Immunology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
- H Michael Belmont
- Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA
- Ilfita Sahbudin
- Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
- Karim Raza
- 15 Centre for Musculoskeletal Ageing Research and Research into Inflammatory Arthritis, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
- Maria Dall'Era
- Rheumatology Division and Russell/Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA, USA
- Jill P Buyon
- Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA
- Diane L Kamen
- Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, USA
- Karen Salomon-Escoto
- Kazuyoshi Ishigaki
- Patrick Dunn
- David Wofsy
- Rheumatology Division and Russell/Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA, USA
- Michele Bombardieri
- Vivian Bykerk
- Myles Lewis
- Ming Wu
- Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA
- Soumya Raychaudhuri
- Hemant Suryawanshi
- Thomas Tuschl
- Christopher Ritchlin
- Maureen McMahon
- Jennifer Grossman
- Philip M Carlucci
- Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA
- Alessandra Nerviani
- Peter M Izmirly
- Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA
- Fan Zhang
- Felice Rivellese
- Joan Bathon
- Zhu Zhu
- Qian Xiao
- Jessica Li
- Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA
- Holden Maecker
- Nir Hacohen
- Rong Mao
- Jennifer Anolik
- Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA
- Javier Rangel-Moreno
- Nida Meednu
- Susan Goodman
- Lindsy Forbess
- Mariko Ishimori
- Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA
- Kevin Deane
- David Hildeman
- Yuhong Li
- Laura Hughes
- Robert Clancy
- ANNE DAVIDSON
- Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA
- Matthias Kretzler
- Larry Moreland
- Harris Perlman
- Peter Gregersen
- Celine C Berthier
- Internal Medicine, Department of Nephrology, University of Michigan, Ann Arbor, MI, USA
- Andrea Fava
- Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA
- David Boyle
- Derek M Fine
- Division of Nephrology, Johns Hopkins University, Baltimore, MD, USA
- Ami Ben-Artzi
- P J Utz
- Melanie Smith
- Beatrice Goilav
- Carla Cuda
- Andrew McDavid
- Deepak A Rao
- Division of Rheumatology, Inflammation, Immunity, Department of Medicine, Brigham and Women`s Hospital, Harvard Medical School, Boston, MA, USA
- Joshua Keegan
- Ilya Korsunsky
- Joel Guthridge
- Kevin Wei
- Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
- Arnon Arazi
- Thomas Eisenhaure
- Michael Brenner
- Susan Macwana
- Pavel Morozov
- Manjunath Kustagi
- Gerald Watts
- Kristina K Deonaraine
- Division of Rheumatology, New York University Grossman School of Medicine, New York, NY, USA
- Jose Monroy-Trujillo
- Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA
- Mohamed G Atta
- Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA
- Kristin Haag
- Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA
- William Apruzzese
- Division of Rheumatology, Inflammation, Immunity, Department of Medicine, Brigham and Women`s Hospital, Harvard Medical School, Boston, MA, USA
- Sean Connery
- Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA
- Fernanda Payan-Schober
- Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA
- Kerry Cho
- Nephrology Division, University of California San Francisco, San Francisco, CA, USA
- Jennifer Goff
- Author
- Aparna Nathan
- Joseph Mears
- Nghia Millard
- Kathryn Weinand
- Saori Sakaue
- Bill Robinson
- Wade DeJager
- Louis Bridges
- Laura Donlin
- Edward DiCarlo
- Amit Lakhanpal
- Heather Sherman
- Anvita Singaraju
- Lorien Shakib
- Brendan Boyce
- Darren Tabechian
- Jen Albrecht
- James Lederer
- A Helena Jonsson
- Daimon Simmons
- Gregory Keras
- Adam Chicoine
- Zhihan Jian Li
- Mandy McGeachy
- Gary Firestein
- Arnold Ceponis
- Diane Horowitz
- Salina Dominguez
- Arthur Mandelin
- Anjali Thakrar
- Mike Holers
- Jennifer Seifert
- Constanino Pitzalis
- Ellen Gravallese
- Jennifer Barnas
- Raymond Hsu
- Steven Woodle
- Paul Hoover
- Michael Peters
- Tony Jones
- David Lieb
- Jeffrey Hodgin
- Raji Menon
- DOI
- https://doi.org/10.1136/lupus-2021-000522
- Journal volume & issue
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Vol. 8,
no. 1
Abstract
Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required.
