A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2

Qingrui Huang; Kai Ji; Siyu Tian; Fengze Wang; Baoying Huang; Zhou Tong; Shuguang Tan; Junfeng Hao; Qihui Wang; Wenjie Tan; George F. Gao; Jinghua Yan

doi:10.1038/s41467-021-21037-2

Nature Communications (Feb 2021)

A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2

Qingrui Huang,
Kai Ji,
Siyu Tian,
Fengze Wang,
Baoying Huang,
Zhou Tong,
Shuguang Tan,
Junfeng Hao,
Qihui Wang,
Wenjie Tan,
George F. Gao,
Jinghua Yan

Affiliations

Qingrui Huang: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Kai Ji: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Siyu Tian: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Fengze Wang: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Baoying Huang: MHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC
Zhou Tong: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Shuguang Tan: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Junfeng Hao: Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences
Qihui Wang: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Wenjie Tan: MHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC
George F. Gao: University of Chinese Academy of Sciences
Jinghua Yan: CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-021-21037-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Several mRNA-based vaccines for SARS-CoV-2 are in late phase clinical development. Here, the authors show that a single immunization with a mRNA vaccine expressing SARS-CoV-2 spike RBD induces neutralizing antibodies that are maintained for at least 6.5 months and confer protection in a sera transfer study in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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