A case of improved quality of life in a patient with inoperable pancreatic cancer after repeated RFA

Nino Toria, MD; Nino Kikodze, PhD; Nona Janikashvili, PhD; Ia Pantsulaia, PhD; Malkhaz Mizandari, MD, PhD; Tinatin Chikovani, MD, PhD; Nagy Habib, MD, PhD

Radiology Case Reports (Oct 2022)

A case of improved quality of life in a patient with inoperable pancreatic cancer after repeated RFA

Nino Toria, MD,
Nino Kikodze, PhD,
Nona Janikashvili, PhD,
Ia Pantsulaia, PhD,
Malkhaz Mizandari, MD, PhD,
Tinatin Chikovani, MD, PhD,
Nagy Habib, MD, PhD

Affiliations

Nino Toria, MD: Department of Immunology, Tbilisi State Medical University, 33 Vazha-Pshavela Ave, Tbilisi, 0186, Georgia
Nino Kikodze, PhD: Department of Immunology, Tbilisi State Medical University, 33 Vazha-Pshavela Ave, Tbilisi, 0186, Georgia; V. Bakhutashvili Institute of Medical Biotechnology, Tbilisi State Medical University, Tbilisi, Georgia
Nona Janikashvili, PhD: Department of Immunology, Tbilisi State Medical University, 33 Vazha-Pshavela Ave, Tbilisi, 0186, Georgia; Corresponding author.
Ia Pantsulaia, PhD: Department of Immunology, Tbilisi State Medical University, 33 Vazha-Pshavela Ave, Tbilisi, 0186, Georgia; V. Bakhutashvili Institute of Medical Biotechnology, Tbilisi State Medical University, Tbilisi, Georgia
Malkhaz Mizandari, MD, PhD: Department of Interventional Radiology, Tbilisi State Medical University, Tbilisi, Georgia
Tinatin Chikovani, MD, PhD: Department of Immunology, Tbilisi State Medical University, 33 Vazha-Pshavela Ave, Tbilisi, 0186, Georgia
Nagy Habib, MD, PhD: Department of Surgery and Cancer, Hammersmith Hospital, Imperial College London, London, UK

Journal volume & issue: Vol. 17, no. 10
pp. 3607 – 3610

Abstract

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Radiofrequency ablation (RFA) has widespread popularity due to its immune-modulation effects in many cancers. Optimal settings to apply RFA in pancreatic cancer, in which the advanced stage of the tumor at the diagnosis makes various therapeutic approaches fail, are still demanding. We report the case of a patient with unresectable pancreatic cancer in which 3 repetitive RFA has been applied over a period of 3 months. Results revealed an improvement in the patient's clinical condition associated with the reduced incidence of CD4+CD45RO+ T lymphocytes and declined TGF-β level in serum. The good quality of life and disease-free survival were maintained for the next months. Booster application of RFA procedure might be a promising option to improve the quality of life in pancreatic cancer patients.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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