CYP51 Paralogue Structure Is Associated with Intrinsic Azole Resistance in Fungi

N. Van Rhijn; M. Bromley; M. Richardson; P. Bowyer

doi:10.1128/mBio.01945-21

mBio (Oct 2021)

CYP51 Paralogue Structure Is Associated with Intrinsic Azole Resistance in Fungi

N. Van Rhijn,
M. Bromley,
M. Richardson,
P. Bowyer

Affiliations

N. Van Rhijn: ORCiD; Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, United Kingdom
M. Bromley: Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, United Kingdom
M. Richardson: Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, United Kingdom
P. Bowyer: Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, United Kingdom

DOI: https://doi.org/10.1128/mBio.01945-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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Azole antifungals are the main treatment for fungal disease in humans. Many species are intrinsically resistant to azoles—in other words all members of the species are resistant without prior exposure—and we do not understand why.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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