Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation

G. A. Weiner; S. H. Shah; C. M. Angelopoulos; A. B. Bartakova; R. S. Pulido; A. Murphy; E. Nudleman; R. Daneman; J. L. Goldberg

doi:10.1038/s41467-019-10219-8

Nature Communications (Jun 2019)

Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation

G. A. Weiner,
S. H. Shah,
C. M. Angelopoulos,
A. B. Bartakova,
R. S. Pulido,
A. Murphy,
E. Nudleman,
R. Daneman,
J. L. Goldberg

Affiliations

G. A. Weiner: Neurosciences Graduate Program, University of California, San Diego
S. H. Shah: Neurosciences Graduate Program, University of California, San Diego
C. M. Angelopoulos: Department of Pharmacology, University of California, San Diego
A. B. Bartakova: Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego
R. S. Pulido: Department of Pharmacology, University of California, San Diego
A. Murphy: Department of Pharmacology, University of California, San Diego
E. Nudleman: Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego
R. Daneman: Department of Pharmacology, University of California, San Diego
J. L. Goldberg: Spencer Center for Vision Research, Byers Eye Institute, Stanford University

DOI: https://doi.org/10.1038/s41467-019-10219-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

During retinal development, waves of cholinergic neural activity play a role in retinal circuit development. Here, the authors show that this activity also contributes to layer-specific angiogenesis and formation of the blood-retinal barrier.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal