Nature Communications (Mar 2022)
High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury
- Wei Li,
- Jian Chen,
- Shujie Zhao,
- Tianhe Huang,
- Huiyan Ying,
- Claudia Trujillo,
- Giuseppina Molinaro,
- Zheng Zhou,
- Tao Jiang,
- Wei Liu,
- Linwei Li,
- Yuancheng Bai,
- Peng Quan,
- Yaping Ding,
- Jouni Hirvonen,
- Guoyong Yin,
- Hélder A. Santos,
- Jin Fan,
- Dongfei Liu
Affiliations
- Wei Li
- Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki
- Jian Chen
- Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University
- Shujie Zhao
- Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University
- Tianhe Huang
- State Key Laboratory of Natural Medicines, Department of Pharmaceutical Science, China Pharmaceutical University
- Huiyan Ying
- Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki
- Claudia Trujillo
- Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki
- Giuseppina Molinaro
- Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki
- Zheng Zhou
- Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University
- Tao Jiang
- Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University
- Wei Liu
- Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University
- Linwei Li
- Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University
- Yuancheng Bai
- State Key Laboratory of Natural Medicines, Department of Pharmaceutical Science, China Pharmaceutical University
- Peng Quan
- Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki
- Yaping Ding
- Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki
- Jouni Hirvonen
- Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki
- Guoyong Yin
- Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University
- Hélder A. Santos
- Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki
- Jin Fan
- Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University
- Dongfei Liu
- Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki
- DOI
- https://doi.org/10.1038/s41467-022-28787-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
High drug loading improves therapeutic efficacy and reduces side effects in drug delivery. Here, the authors use controlled diffusion of solvents to precipitate drug nanoparticles in polymer particles while the polymer is solidifying and demonstrate the particles for drug delivery in a spinal cord injury model.
