Real-Time Monitoring of Multistep Batch and Flow Synthesis Processes of a Key Intermediate of Lifitegrast by a Combined Spectrometer System with Both Near-Infrared and Raman Spectroscopies Coupled to Partial Least-Squares

• Quan Liu,
• Chuanjun Wu,
• Huiting Liu,
• Mengfei Wang,
• Chuanmeng Zhao,
• Fuli Zhang

Affiliations

Quan Liu

School of Pharmaceutical Science, Shanghai Jiao Tong University, Shanghai, China

Chuanjun Wu

Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China

Huiting Liu

Shanghai PROXS Chemical Technology Co. Ltd., Shanghai, China

Mengfei Wang

Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China

Chuanmeng Zhao

Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China

Fuli Zhang

Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, China