E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family

Jenny Hsu; Julia Arand; Andrea Chaikovsky; Nancie A. Mooney; Janos Demeter; Caileen M. Brison; Romane Oliverio; Hannes Vogel; Seth M. Rubin; Peter K. Jackson; Julien Sage

doi:10.1038/s41467-019-10901-x

Nature Communications (Jul 2019)

E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family

Jenny Hsu,
Julia Arand,
Andrea Chaikovsky,
Nancie A. Mooney,
Janos Demeter,
Caileen M. Brison,
Romane Oliverio,
Hannes Vogel,
Seth M. Rubin,
Peter K. Jackson,
Julien Sage

Affiliations

Jenny Hsu: Department of Pediatrics, 300 Pasteur Drive, Stanford University
Julia Arand: Department of Pediatrics, 300 Pasteur Drive, Stanford University
Andrea Chaikovsky: Department of Pediatrics, 300 Pasteur Drive, Stanford University
Nancie A. Mooney: Baxter Laboratory, Department of Microbiology & Immunology, 300 Pasteur Drive, Stanford University
Janos Demeter: Baxter Laboratory, Department of Microbiology & Immunology, 300 Pasteur Drive, Stanford University
Caileen M. Brison: Department of Chemistry and Biochemistry, University of California
Romane Oliverio: Department of Pediatrics, 300 Pasteur Drive, Stanford University
Hannes Vogel: Department of Pediatrics, 300 Pasteur Drive, Stanford University
Seth M. Rubin: Department of Chemistry and Biochemistry, University of California
Peter K. Jackson: Baxter Laboratory, Department of Microbiology & Immunology, 300 Pasteur Drive, Stanford University
Julien Sage: Department of Pediatrics, 300 Pasteur Drive, Stanford University

DOI: https://doi.org/10.1038/s41467-019-10901-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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E2F transcription factors are regulators of cell division and cell fate decisions. Here the authors show that E2F4 is important for proliferation and survival of mouse ESCs, independent of the RB family, and that E2F4 interacts with chromatin regulators associated with gene activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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