Nature Communications (Aug 2018)
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
- Mar Quiñones,
- Omar Al-Massadi,
- Cintia Folgueira,
- Stephan Bremser,
- Rosalía Gallego,
- Leonardo Torres-Leal,
- Roberta Haddad-Tóvolli,
- Cristina García-Caceres,
- Rene Hernandez-Bautista,
- Brian Y. H. Lam,
- Daniel Beiroa,
- Estrella Sanchez-Rebordelo,
- Ana Senra,
- Jose A. Malagon,
- Patricia Valerio,
- Marcos F. Fondevila,
- Johan Fernø,
- Maria M. Malagon,
- Raian Contreras,
- Paul Pfluger,
- Jens C. Brüning,
- Giles Yeo,
- Matthias Tschöp,
- Carlos Diéguez,
- Miguel López,
- Marc Claret,
- Peter Kloppenburg,
- Guadalupe Sabio,
- Ruben Nogueiras
Affiliations
- Mar Quiñones
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Omar Al-Massadi
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Cintia Folgueira
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Stephan Bremser
- Biocenter, Institute for Zoology, University of Cologne
- Rosalía Gallego
- Department of Morphological Sciences, School of Medicine, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Leonardo Torres-Leal
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Roberta Haddad-Tóvolli
- Neuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Cristina García-Caceres
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München
- Rene Hernandez-Bautista
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Brian Y. H. Lam
- MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Daniel Beiroa
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Estrella Sanchez-Rebordelo
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Ana Senra
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Jose A. Malagon
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Patricia Valerio
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Marcos F. Fondevila
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Johan Fernø
- KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen
- Maria M. Malagon
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)
- Raian Contreras
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München
- Paul Pfluger
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München
- Jens C. Brüning
- Department of Mouse Genetics and Metabolism, Institute for Genetics and Center for Molecular Medicine (CMMC), University of Cologne
- Giles Yeo
- MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital
- Matthias Tschöp
- Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München
- Carlos Diéguez
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Miguel López
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Marc Claret
- Neuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Peter Kloppenburg
- Biocenter, Institute for Zoology, University of Cologne
- Guadalupe Sabio
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
- Ruben Nogueiras
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- DOI
- https://doi.org/10.1038/s41467-018-05711-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity.
