Nature Communications (Jan 2020)
Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution
Abstract
Imaging mass spectrometry is a powerful emerging tool for mapping the spatial distribution of biomolecules across tissue surfaces. Here the authors showcase an automated technology for deep proteome imaging that utilizes ultrasensitive microfluidics and a mass spectrometry workflow to analyze tissue voxels, generating quantitative cell-type-specific images.