Anesthetic dose correction in hospital pharmacology using bispectral index monitoring technology

Abstract

Background Modern clinical pharmacology insists on the valorization of individual patient's characteristics that influence pharmacokinetic and pharmacodynamics medicine effects. The objective of this work is evaluation of anesthetic doses in patients with larynx benign tumors, operated by applying endoscopic surgical methods and where was used bispectral index monitoring technology during general endotracheal anesthesia. Material and Methods Patients were divided in two groups. Group A was made out of ten patients in which are applied recommended anesthetic doses, while inspection in bispectral index values was possible only after closed anesthesia. Group B was made out of twenty patients with corrected anesthetic doses according to the bispectral index numerical values. Results In the Group A, waking up lasted averagely 120}10 seconds, and in Group B 70}9 seconds (p<0.01). In the Group B, induction dose was 25% lower (p<0.01), observance dose was 15% lower, and total propofol consumption was 25% lower than in Group A (p<0.01). Conclusions It is possible without bispectral index monitoring technology to apply higher anesthetic dose than it is regular. Bispectral index monitoring should become standard in clinical anesthesia.

Keywords

• BIS monitoring technology
• anesthetics - application and dosage
• clinical hospital pharmacology
• dose
• medicine response ratio