Nature Communications (Jun 2021)
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis
- Joshua D. G. Leach,
- Nikola Vlahov,
- Petros Tsantoulis,
- Rachel A. Ridgway,
- Dustin J. Flanagan,
- Kathryn Gilroy,
- Nathalie Sphyris,
- Ester G. Vázquez,
- David F. Vincent,
- William J. Faller,
- Michael C. Hodder,
- Alexander Raven,
- Sigrid Fey,
- Arafath K. Najumudeen,
- Douglas Strathdee,
- Colin Nixon,
- Mark Hughes,
- William Clark,
- Robin Shaw,
- S:CORT consortium,
- Sander R. van Hooff,
- David J. Huels,
- Jan Paul Medema,
- Simon T. Barry,
- Margaret C. Frame,
- Asier Unciti-Broceta,
- Simon J. Leedham,
- Gareth J. Inman,
- Rene Jackstadt,
- Barry J. Thompson,
- Andrew D. Campbell,
- Sabine Tejpar,
- Owen J. Sansom
Affiliations
- Joshua D. G. Leach
- Cancer Research UK Beatson Institute
- Nikola Vlahov
- Cancer Research UK Beatson Institute
- Petros Tsantoulis
- Department of Medical Specialties, Faculty of Medicine, University of Geneva
- Rachel A. Ridgway
- Cancer Research UK Beatson Institute
- Dustin J. Flanagan
- Cancer Research UK Beatson Institute
- Kathryn Gilroy
- Cancer Research UK Beatson Institute
- Nathalie Sphyris
- Cancer Research UK Beatson Institute
- Ester G. Vázquez
- Gastrointestinal Stem Cell Biology Lab, Wellcome Trust Centre for Human Genetics, University of Oxford
- David F. Vincent
- Cancer Research UK Beatson Institute
- William J. Faller
- Division of Oncogenomics, Netherlands Cancer Institute
- Michael C. Hodder
- Cancer Research UK Beatson Institute
- Alexander Raven
- Cancer Research UK Beatson Institute
- Sigrid Fey
- Cancer Research UK Beatson Institute
- Arafath K. Najumudeen
- Cancer Research UK Beatson Institute
- Douglas Strathdee
- Cancer Research UK Beatson Institute
- Colin Nixon
- Cancer Research UK Beatson Institute
- Mark Hughes
- Cancer Research UK Beatson Institute
- William Clark
- Cancer Research UK Beatson Institute
- Robin Shaw
- Cancer Research UK Beatson Institute
- S:CORT consortium
- Sander R. van Hooff
- Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center
- David J. Huels
- Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center
- Jan Paul Medema
- Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center
- Simon T. Barry
- Bioscience, Early Oncology, AstraZeneca
- Margaret C. Frame
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Asier Unciti-Broceta
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
- Simon J. Leedham
- Gastrointestinal Stem Cell Biology Lab, Wellcome Trust Centre for Human Genetics, University of Oxford
- Gareth J. Inman
- Cancer Research UK Beatson Institute
- Rene Jackstadt
- Cancer Research UK Beatson Institute
- Barry J. Thompson
- EMBL Australia, John Curtin School of Medical Research, The Australian National University
- Andrew D. Campbell
- Cancer Research UK Beatson Institute
- Sabine Tejpar
- Molecular Digestive Oncology, Department of Oncology, University of Leuven
- Owen J. Sansom
- Cancer Research UK Beatson Institute
- DOI
- https://doi.org/10.1038/s41467-021-23717-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and inflammation induce the development of colonic tumours with a foetal-like phenotype.
