PLoS ONE (Jan 2011)

Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.

  • Manal Khalifé,
  • Rachel Young,
  • Bruno Passet,
  • Sophie Halliez,
  • Marthe Vilotte,
  • Florence Jaffrezic,
  • Sylvain Marthey,
  • Vincent Béringue,
  • Daniel Vaiman,
  • Fabienne Le Provost,
  • Hubert Laude,
  • Jean-Luc Vilotte

DOI
https://doi.org/10.1371/journal.pone.0023253
Journal volume & issue
Vol. 6, no. 8
p. e23253

Abstract

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The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was performed at early embryonic stages. RNAseq analysis revealed the differential expression of 73 and 263 genes at E6.5 and E7.5, respectively. The related metabolic pathways identified in this analysis partially overlap with those described in PrP1 and PrP2 knockdown zebrafish embryos and prion-infected mammalian brains and emphasize a potentially important role for the PrP family genes in early developmental processes.