Structure-Guided Design of a Synthetic Mimic of an Endothelial Protein C Receptor-Binding PfEMP1 Protein

Natalie M. Barber; Clinton K. Y. Lau; Louise Turner; Gareth Watson; Susan Thrane; John P. A. Lusingu; Thomas Lavstsen; Matthew K. Higgins

doi:10.1128/mSphere.01081-20

mSphere (Feb 2021)

Structure-Guided Design of a Synthetic Mimic of an Endothelial Protein C Receptor-Binding PfEMP1 Protein

Natalie M. Barber,
Clinton K. Y. Lau,
Louise Turner,
Gareth Watson,
Susan Thrane,
John P. A. Lusingu,
Thomas Lavstsen,
Matthew K. Higgins

Affiliations

Natalie M. Barber: Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Clinton K. Y. Lau: Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Louise Turner: Centre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark
Gareth Watson: Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Susan Thrane: Centre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark
John P. A. Lusingu: National Institute for Medical Research, Dar es Salaam, Tanzania
Thomas Lavstsen: ORCiD; Centre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark
Matthew K. Higgins: ORCiD; Department of Biochemistry, University of Oxford, Oxford, United Kingdom

DOI: https://doi.org/10.1128/mSphere.01081-20
Journal volume & issue: Vol. 6, no. 1

Abstract

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Vaccines train our immune systems to generate antibodies which recognize pathogens. Some of these antibodies are highly protective, preventing infection, while others are ineffective.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal