Nature Communications (May 2020)

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

  • Katarína Tiklová,
  • Sara Nolbrant,
  • Alessandro Fiorenzano,
  • Åsa K. Björklund,
  • Yogita Sharma,
  • Andreas Heuer,
  • Linda Gillberg,
  • Deirdre B. Hoban,
  • Tiago Cardoso,
  • Andrew F. Adler,
  • Marcella Birtele,
  • Hilda Lundén-Miguel,
  • Nikolaos Volakakis,
  • Agnete Kirkeby,
  • Thomas Perlmann,
  • Malin Parmar

DOI
https://doi.org/10.1038/s41467-020-16225-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-clinical rat model for Parkinson’s disease and identify perivascular-like cells.