Фармакокинетика и Фармакодинамика (Feb 2019)

Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF

  • O. G. Gribakina,
  • R. V. Shevchenko,
  • G. B. Kolyvanov,
  • A. A. Litvin,
  • P. O. Bochkov,
  • S. S. Boyko,
  • V. P. Zherdev

DOI
https://doi.org/10.24411/2587-7836-2019-10046
Journal volume & issue
Vol. 0, no. 2
pp. 41 – 45

Abstract

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He technique of quantitative determination of a new compound GIZH-298 in the rat blood plasma was developed and validated. Analysis was performed by HPLC-UV. The method was linear in the range of 100-5000 ng/ml. Recovery of GIZH-298 was 86,88 %. Limit of detection was 100 ng/ml.

Keywords